Welcome to Micro-Fluidics & Micro-Fabrication (uf2) Laboratory. The uf2 laboratory affiliated with Department of Mechanical Engineering at National Central University, Taiwan and directed by Professor Chia-Wen Tsao. Our research focus on microfluidics and micro/nano-fabrication technologies in microfluidics, lab-on-a-chip and mass spectrometry.
DR. CHIA-WEN (KEVIN) TSAO
Experience & Expertise
EDUCATION
Doctor of Philosophy (Ph.D.) May/2008
University of Maryland at College Park, College Park, MD, USA
Department of Mechanical Engineering
Master of Science (M.S.) Aug/2004
University of Colorado at Boulder, Boulder, CO, USA
Department of Mechanical Engineering
Bachelor of Science (B.S.) May/1998
Yuan-Ze University, Taoyuan, Taiwan
Department of Mechanical Engineering
EXPERIENCE
Professor 08/2017 to now
Department of Mechanical Engineering, National Central University, Taoyuan, Taiwan
Director 04/2019 to 01/2020
Center for Academia and Industry Collaboration, National Central Universtiy,Taoyuan, Taiwan
Deputy Director 08/2018 to 04/2019
Center for Academia and Industry Collaboration, National Central Universtiy,Taoyuan, Taiwan
Associate Professor 08/2013 to 07/2017
Department of Mechanical Engineering, National Central University, Taoyuan, Taiwan
Assistant Professor 08/2008 to 07/2013
Department of Mechanical Engineering, National Central University, Taoyuan, Taiwan
Research Assistant 06/2005 to 05/2008
Maryland Microfluidic Lab University of Maryland, College Park, MD USA
MEMS Engineer 08/2004 to 05/2005
Touch Micro System Inc. Taoyuan, Taiwan
Research Assistant 08/2002 to 08/2004
Fluid Dynamics Laboratory, University of Colorado, Boulder, CO USA
Mechanical Engineer 06/2000 to 06/2002
AeroVision Avionics, Inc. Hsinchu, Taiwan
HONORS, AWARDS & RECOGNITIONS
‧ 2023 World's Top 2% Scientists - Single recent year impact (全球前2%頂尖科學家)
‧ 2022 World's Top 2% Scientists - Single recent year impact (全球前2%頂尖科學家)
‧ 2021 World's Top 2% Scientists - Single recent year impact (全球前2%頂尖科學家)
‧ Certificate in EMI (English as a Medium of Instruction) Skills, Cambridge English Language Assessment
‧ ”Polymer Microfluidics: Simple, Low-Cost Fabrication Process Bridging Academic Lab Research to Commercialized Production” is top 1% highly cited paper in the academic field of 「Engineering」 as of July/August 2020 (Web of Science)
‧2020 Best Paper Award, ICSS 2020 International Conference on Smart Sensors, Oct. 19-20, 2020
‧2019 Lab member S.M. Wang (M.S student) receive 2019 Humanoid Taiwan, Robo-one Champion
‧2018 Outstanding Alumni Award, Department of Mechanical Engineering, Yuan-Ze University
‧2017 National Central University Outstanding Research Award
‧2013 National Central University Outstanding Research Award
‧2008 National Central University Young Faculty Award
‧“Bonding of thermoplastic polymer microfluidics” is the top cited paper Top 5 most cited articles from the time period 2008 and 2009 in Microfluidics and Nanofluidics (SCI, IF=3.504)
‧"Fabrication of nanostructured silicon by metal-assisted etching and its effects on matrix-free laser desorption/ionization mass spectrometry" Selected as Analytica Chimica Acta (SCI, IF=4.310) Featured article
GROUP MEMBER
楊子頤
機械工程學系碩士班二年級
趙詠綺
機械工程學系碩士班二年級
林千妤
機械工程學系碩士班二年級
鍾晨鴻
機械工程學系碩士在職專班
陳冠呈
機械工程學系碩士在職專班
江蕙瑀
機械工程學系碩士班一年級
樊家維
機械工程學系碩士班一年級
洪乃仁
機械工程學系碩士班一年級
高上育
機械工程學系碩士班一年級
PUBLICATION LIST
Journal Paper
Chia-Wen Tsao*, and Ping-Chin Shen “Maskless patterning of metal nanoparticles and silicon nanostructures by droplet deposition and etching process” Materials Advances, 2023, DOI: 10.1039/D3MA00380A
Hu, Wei-Wen; Chen, Yen-Chi; Tsao, Chia-Wen; Chen, Shen-Liang; Tzeng, Chung-Yuh "Development of a multifunctional bioreactor to evaluate the promotion effects of cyclic stretching and electrical stimulation on muscle differentiation" Bioengineering & Translational Medicine
Qun-Zhan Huang, Jyun-Cong Huang, Chia-Wen Tsao, and Shao-Yiu Hsu “Pore doublet micromodel experiments of evaporation influence on pre-event water entrapment and pre-event and event water interaction” Advances in Water Resources, 2023. 177: p. 104464.
Wen-Pin Hu, Yi-Fang Lai, Cao-An Vu, Chia-Wen Tsao, Shin-Chen Pan, Chao-Min Cheng, Wen-Yih Chen “The paper/PMMA hybrid device with a microvalve-controlled design for exosome isolation and analysis” Talanta, 2023. 265: p. 124851
Chia-Wen Tsao*, Chang-Yen Chang, Wei-Wen, Hu, and Yun-Shan Tian “Bonding of thermoplastic microfluidic device by water assistance” International Journal of Adhesion and Adhesives, 2023. 125: p. 103429
Wei-Wen Hu, Shih-Yung Yang, Chia-Wen Tsao*, Shen-Liang Chen, Chung-Yuh Tzeng, “Deposition of polypyrrole on wrinkled polydimethylsiloxane to fabricate stretchable conductive membranes for multifunctional bioreactor applications” Progress in Organic Coatings, 2023. 181: p. 107573.
Ahmed A. Shalaby, Chia-Wen Tsao, Akihiko Ishida, Masatoshi Maeki, and Manabu Tokeshi “Microfluidic Paper-Based Analytical Devices for Cancer Diagnosis” Sensors and Actuators B: Chemical, Volume 379, 15 March 2023, 133243
Chia-Wen Tsao*, Chang-Yen Chang and Po-Yen Chien “Microwave-assisted solvent bonding for polymethyl methacrylate microfluidic device” Micromachines, 2022 Jul 17;13(7):1131.
(Featured article) Kiran Giri and Chia-Wen Tsao*, “Recent Advances in Thermoplastic Microfluidic Bonding” Micromachines 2022, 13(3), 486
Yi-Hsuan Shih, Shao-Yiu Hsu, Qun-Zhan Huan, Krzysztof Lamorski, Ming-Che Hu, Chia-Wen Tsao, Cezary Sławiński and Nima Shokri “Euler Characteristic during Drying of Porous Media” Drying Technology, 2022 40:4, pages 689-690.
Chia-Wen Tsao*, You-Shan Zheng, Ya-Sen Sun, and Yu-Che Cheng “Surface-enhanced Raman scattering (SERS) spectroscopy on localized silver nanoparticles decorated porous silicon substrate” Analyst, 2021, 146, 7645-7652
Chia-Wen Tsao* and Zhong-Ming Guo “Electrochemical Sensing on a Nanostructured Silicon Mass Spectrometry Surface” Austin Journal of Nanomedicine and Nanotechnology. 2021; 9(1): 1064
Chia-Wen Tsao, Qun-Zhan Huang, Cheng-Ye Yu, Shao-Yiu Hsu, Krzysztof Lamorski, Liang-Cheng Chang, and Cezary Sławiński “The effect of channel aspect ratio on air entrapment during imbibition in soil-on-a-chip micromodels with 2D and 2.5D pore structures” Lab on a Chip, 2021, 21, 385
Chia-Wen Tsao* and Zheng-Kun Wu “Polymer Microchannel and Micromold Surface Polishing for Rapid, Low-Quantity Polydimethylsiloxane and Thermoplastic Microfluidic Device Fabrication” Polymers 2020, 12, 2574
Chia-Wen Tsao* and Wan-Ci Syu “Bonding of thermoplastic microfluidics by dry adhesive tapes” RSC Advances, 2020, 10, 30289 - 30296
Wei-Wen Hu, Tun-Chi Chen, Chia-Wen Tsao, and Yu-Che Cheng “The effects of substrate-mediated electrical stimulation on the promotion of osteogenic differentiation and its optimization” The Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2018 1-13
Chen, Pi-Yu; Hsieh, Chi-Ying; Shih, Chao-Jen; Lin, Yuan-Jing; Tsao, Chia-Wen; Yang, Yu-Liang "Exploration of Fungal Metabolic Interactions Using Imaging Mass Spectrometry on Nanostructured Silicon” Journal of Natural Products,2018, 81 1527–1533
Chia-Yi Yen, Moh-Ching O. Chang, Zong-Fu Shih, Yi-Hsing Lien and Chia-Wen Tsao* “Cyclic Block Copolymer Microchannel Fabrication and Sealing for Microfluidics Applications” Inventions 2018, 3(3), 49
Xu-Cheng Guo, Wei-Wen Hu, Say Hwa Tan and Chia-Wen Tsao* “A Stretchable Conductive Polypyrrole Polydimethylsiloxane Device Fabricated by Simple Soft Lithography and Oxygen Plasma Treatment” Biomedical Microdevices. 2018;20(2):30
Chia-Wen Tsao*, I-Chao Lei, Pi-Yu Chen and Yu-Liang Yang “Piezo-Ring-on-Chip Microfluidic Device for Simple and Low-Cost Mass Spectrometry Interfacing” Analyst, 143, 981-988, 2018
Shao-Yiu Hsu, Zhong-Yao Zhang and Chia-Wen Tsao* “Thermoplastic micromodel investigation of two-phase flows in a fractured porous medium” Micromachines 2017, 8, 38
Heng-Dong Xi, Hao Zheng, Wei Guo, Alfonso M Gañán-Calvo, Ye Ai, Chia-Wen Tsao, Jun Zhou, Weihua Li, Yanyi Huang, Nam-Trung Nguyen and Say Hwa Tan “Active droplet sorting in microfluidics: a review”. Lab Chip, 2017,17, 751-771 (featured as cover image)
Adrian J.T. Teo, Holden King-Ho Li, Nam-Trung Nguyen, Wei Guo, Nadine Heere, Heng-Dong Xi, Chia-Wen Tsao, Weihua Li, and Say Hwa Tan “Negative Pressure Induced Droplet Generation in a Microfluidic Flow-focusing Device” Analytical Chemistry , 2017, 89 (8), pp 4387–4391 (featured as cover image)
Chia-Wen Tsao* “Polymer microfluidics: Simple, low-cost fabrication process bridging academic lab research to commercialized production” Micromachines 2016, 7(12), 225;
Chia-Wen Tsao*, Xu-Cheng Guo and Wei-Wen Hu “Highly stretchable conductive polypyrrole film on three dimensional porous polydimethylsiloxane surface fabricated by simple soft lithography process” RSC Advances, 2016, 6, 113344-113351
Chia-Wen Tsao*, Yuan-Jing Lin , Pi-Yu Chen and Yu-Liang Yang and Say Hwa Tan “Nanoscale silicon surface-assisted laser desorption/ionization mass spectrometry: Environment stability and activation by simple vacuum oven desiccation” Analyst, 2016,141, 4973-4981
Chia-Wen Tsao* and Yueh-Pu Lee “Magnetic microparticle-polydimethylsiloxane composite for reversible microchannel bonding” Science and Technology of Advanced Materials, 2016, Vol. 17, No. 1, 2–11
Chia-Wen Tsao*, Wen-Yih Chen, Chien-Han Lin and Yu-Che Cheng “Nanostructured Silicon Substrate for Desorption/Ionization on Silicon Mass Spectrometry Coupled with Titanium Oxide and Zinc Oxide Coated Magnetic Nanoparticles for Phosphopeptide Analysis” Journal of nanoscience and nanotechnolgy, Vol. 16, 1–7, 2016
Chia-Wen Tsao* and Zhi-Jie Yang “High Sensitivity and High Detection Specificity of Gold-Nanoparticle-Grafted Nanostructured Silicon Mass Spectrometry for Glucose Analysis” ACS applied materials & interfaces, 2015 Oct 14;7(40):22630-7.
Chia-Wen Tsao*, Yu-Che Cheng, and Jhih-Hao Cheng “Fluid flow shear stress stimulation on a multiplex microfluidic device for rat bone marrow stromal cells differentiation enhancement” Micromachines 2015, 6(12), 1996-2009
Shao-Li Han, Meng‑Jie Xie, Chih‑Cheng Chien, Yu‑Che Cheng, and Chia‑Wen Tsao* “Using MEMS‑based inertial sensor with ankle foot orthosis for telerehabilitation and its clinical evaluation in brain injuries and total knee replacement patients” Microsystem technologies,pp. 1-10, 2015/02/03 2015
Chia-Wen Tsao*, Ke-Siang Chen, and Feng-Nan Hwang “Numerical Simulation of Droplet-Based Microfluidic Chip Interfacing with Laser Desorption/Ionization Mass Spectrometry Target Substrate” Micro & Nano Letters, IET, vol. 10, pp. 192-197, 2015
Y.-C. Cheng, C.-W. Tsao*, M.-Z. Chiang, C.-A. Chung, C.-C. Chien, W.-W. Hu, R-C Ruaan and C. Li, “Microfluidic platform for human placenta-derived multipotent stem cells culture and applied for enhanced neuronal differentiation”, Microfluidics and Nanofluidics, (2014) 1-12
Shao-Kuan Chen, Chih-Ang Chung, Yu-Che Cheng, Chi-Jung Huang, Wen-Yih Chen, Ruoh-Chyu Ruaan, Chuan Li, Chia-Wen Tsao, Wei-Wen Hu, and Chih-Cheng Chien “Toll-like Receptor 6 and Connective Tissue Growth Factor are significantly upregulated in mitomycin-C treated urothelial carcinoma cells under hydrostatic pressure stimulation” Genetic Testing and Molecular Biomarkers 18(6):410-6, 2014
Atsushi Hattori, Tohru Yagi and Chia-Wen Tsao “A Study on Encapsulation of Single-Cell into Fixed Droplets Using Triangular Microwells” IEEJ Transactions on Electronics, Information and Systems Vol. 134 (2014) No. 6 P 848-855
Wei-Wen Hu, Yi-Ting Hsu, Yu-Che Cheng, Chuan Li, Ruoh-Chyu Ruaan, Chih-Cheng Chien, Chih-Ang Chung, and Chia-Wen Tsao “Electrical stimulation to promote osteogenesis using conductive polypyrrole films” Materials Science and Engineering C. 37 (2014) 28–36
Shao-Kuan Chen, Chih-Ang Chung, Yu-Che Cheng, Chi-Jung Huang, Ruoh-Chyu Ruaan, Wen-Yih Chen, Chuan Li, Chia-Wen Tsao, Wei-Wen Hu and Chih-Cheng Chien “Hydrostatic pressure enhances mitomycin C induced apoptosis in urothelial carcinoma cells” Urologic Oncology: Seminars and Original Investigations, 32(2014)26.e17–26.e24
Feng-Nan Hwang, Xiao-Chuan Cai, Yu-Lun Cheng, Chia-Wen Tsao* "A Parallel Fully Coupled Implicit Domain Decomposition Method for Numerical Simulation of Microfluidic Mixing in 3D", International Journal of Computer Mathematics, Volume 90, Issue 3, 2013
Wei-Wen Hu, Wun-Jheng Syu, Wen-Yih Chen, Ruoh-Chyu Ruaan, Yu-Che Cheng, Chih-Cheng Chien, Chuan Li, Chih-Ang Chung and Chia-Wen Tsao “Use of Biotinylated Chitosan for Substrate-Mediated Gene Delivery” Bioconjugate Chem, 2012, 23 (8), pp 1587–1599
Chia-Wen Tsao*, Cheng-Wei Chung and Zhi-Jie Yang “Preparation of nanostructured silicon surface for mass spectrometry analysis by an all-wet fabrication process using electroless metal deposition and metal assisted etching” International Journal of Mass Spectrometry, 321– 322 (2012) 8– 13
Yi-Teng Hsiao, Jing-Hui Wang, Yi-Chun Hsu, Chien-Chun Chiu, Chien-Jung Lo, Chia-Wen Tsao, Wei Yen Woon “Collective hydrodynamics confinement in bacterial carpet microfluidic channel” Appl. Phys. Lett. 100, 203702 (2012)
C. W. Tsao, C.H. Lin, Y.C. Cheng, C.C. Chien, and W.Y. Chen “Nanostructured silicon surface modifications for as a selective matrix-free laser desorption/ionization mass spectrometry” Analyst, 2012, 137, 2643-2650
Chia-Wen Tsao* and Tzug-Yi Chen “Rapid polymer microchannel fabrication by hot roller embossing process” Microsystem Technologies, Volume 18, Issue 6, pp 713-722, 2012
Yu-Che Cheng, Kun-Han Chen, Juo-Shin Wang, Wen-Liu Hsu, Chih-Cheng Chien, Wen-Yih Chen, and Chia-Wen Tsao* “Rapid Analysis of Abused Drugs Using Nanostructured Silicon Surface Assisted Laser Desorption/Ionization Mass Spectrometry” Analyst, 2012, 37, 654-661
Chia-Wen Tsao* and Chia-Pin Chang “Effects of Metal Layer Morphology to Silicon Nanostructure Formation in Metal-Assisted Etching” Journal of Nanoscience and Nanotechnology, 2012,Volume 12, Number 3, March 2012 , pp. 2742-2749(8)
W. Y. Chen, J. T. Huang, Y. C. Cheng, C. C. Chien, and C. W. Tsao*, "Fabrication of nanostructured silicon by metal-assisted etching and its effects on matrix-free laser desorption/ionization mass spectrometry" Analytica Chimica Acta, vol. 687, pp. 97-104, 2011.
Huang, H.I., Cheng, Y.C., Chen W.Y., Tsao, C.W., Huang C.J., Liu, H.T., and Chien, C.C. “Comparative proteomic analysis of placenta-derived multipotent cells (PDMCs) and its differentiated neuron.” The Chinese J. Pain. 2010, 20(1), 01-11.
Chia-Wen Tsao, Song Tao, Chien-Fu Chen, Jikun Liu, and Don L. DeVoe “Interfacing microfluidics to LDI-MS by automatic robotic spotting” Microfluidics and Nanofluidics, Volume 8, (2010) Issue 6, Page 777
J. Liu, C.F. Chen, C.W. Tsao, C. C. Chang, C. C. Chu, and D. L. DeVoe ” Polymer Microchips Integrating Solid-Phase Extraction and High-Performance Liquid Chromatography Using Reversed-Phase Polymethacrylate Monoliths” Analytical Chemistry, 81 (7), pp. 2545-2554, 2009
C.W. Tsao* and D. L. DeVoe “Bonding of thermoplastic polymer microfluidics” Microfluidics and Nanofluidics, 6,1–16 2009 (Top 5 most cited articles from the time period 2008 and 2009)
C. F. Chen, J. Liu, L. P. Hromada, C.W. Tsao, C. C. Chang and D. L. DeVoe “High-pressure needle interface for thermoplastic microfluidics” Lab ON A CHIP, 9, 50 – 55, 2009
C.W. Tsao, P. Kumar, J. Liu and D.L. DeVoe "Dynamic electrowetting on nanofilament silicon for matrix-free laser desorption/ionization mass spectrometry" Analytical Chemistry, vol. 80, pp. 2973-2981, 2008
C.W. Tsao, J. Liu and D.L. DeVoe " Droplet formation from hydrodynamically coupled capillaries for parallel microfluidic contact spotting " Journal of Micromechanics and Microengineering, vol. 18, pp. 025013, 2008
C.W. Tsao, L. Hromada, J. Liu, P.Kumar and D.L. DeVoe "UV/Ozone Surface Treatment of PMMA and COC Microfluidic Substrates" LAB ON A CHIP 7 (4): 499-505 2007
CONTACT US
If you want to contact us...
We are located in the Department of Mechanical Engineering, National Central University, Taiwan
Prof. Chia-Wen (Kevin) Tsao
Email: cwtsao@ncu.edu.tw
Tel: +886-3-4267343
Office Address: Room E4-366 No. 300, Zhongda Rd., Zhongli District, Taoyuan City 32001, Taiwan
uf2 Lab Address: Room E4-252 No. 300, Zhongda Rd., Zhongli District, Taoyuan City 32001, Taiwan
uf2 Lab TEL: +886-3-4227151 ext.37317